US drugs giant Pfizer has withdrawn its £55 a share, £69bn takeover bid for UK pharmaceutical firm AstraZeneca.
It said: "Following the AstraZeneca board's rejection of the proposal, Pfizer announces that it does not intend to make an offer."
AstraZeneca's chairman, Leif Johansson, said it would "continue building on the momentum we have already demonstrated as an independent company."
AstraZeneca had fiercely resisted the bid, backed by some politicians.
It rejected a final offer from Pfizer earlier this month, saying the proposal undervalued the company and its "attractive prospects".
Nevertheless, in recent weeks some AstraZeneca shareholders had said they wanted the firm to engage with Pfizer.
But Mr Johansson said: "We have attractive growth prospects and a rapidly progressing pipeline. In the coming months we anticipate positive news flow across our core therapeutic areas, which underpins our confidence in the long-term prospects of the business."
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